Do you mean saying "fuck it all" and just lazing around, or saying "fuck you" to humanity and being a giant irritable prick for a while?
Because the latter is my general disposition anyways.
As for the former, I'm sort of in that mode right now. My dad is going through some difficult times - he's been unemployed for two years, is obese to the point of affecting health/mobility, and is suffering from gout/arthritis in his knees/legs at the same time - and has needed to move to a smaller apartment. He had no money for movers or even the cheapest U-Haul truck, and neither did I as I just made my one yearly football purchase (Michigan vs Illinois tickets, tailgating in Champaign for the MAIZE AND BLUE!). So while it was gonna be difficult with some of the bigger furniture and his tall and unwieldy computer desk, we figured we just call some friends up and offer the usual pizza/beer and get this done.
No dice.
NO ONE could or would help. Not a single person; my brother-in-law was here for about a hour before he started feeling abdominal pain and went to the hospital, where apparently he sprained or ruptured or did something to his pancreas. So I've had to move my dad into his new apartment on my own, couches and all. Keep in mind I'm all of 5 feet tall with the corresponding small armspan. And in the middle of this, I got a phone call from a out-of-state friend. He recently got engaged and I'm slated to be in the wedding party as a groomsman. Well his fiancee has had some heart issues for a while and they came to a head; apparently her heart is too weak to fully pump throughout her body. Her lungs almost stopped operating because of this. She's now continually hospitalized, on the transplant list but it doesn't look good. So after a quick shower, I drove 5 hours to Indianapolis to be with them for all of Sunday before driving the 5 hours back and getting right back to the moving. I've had maybe 6 hours total of sleep since this all started last Thursday.
So yeah, right now I'm in one big sore-and-tired "fuck it" mood.