I Am Legend
I never got around to reading the book, the movie was good in my opinion.
But every time that dog dies.. I can't help but shed a tear. Nevilles all alone, that dog is all he's got in the world that his daughter left him and she gave her life to save him and afterwards he couldn't save her
That's up there with Old Yeller and Where The Red Fern Grows in terms of guaranteed-tears