It hasn't been as bad as I thought, but I have my issues with it. I also don't like the female lead. But then, I outright hated JD by the end of second season and I still loved the show as a whole.
Denise was my favourite intern from season 9 BY FAR, so I'm super glad she's back. Dr. Cox remains as funny as ever as well. But these security guys are certainly no Janitor. I hope they can round out the cast with some more strong leads and in classic Scrubs style, get some fantastic ringers. I think the brilliance of characters like Jordan, Ted, the Todd, and Janitor came from the fact that they were never intended to be recurring characters, they were just really funny. Here though it seems like they're intentionally trying to throw in funny side characters, and so these characters are just instantly annoying instead. (I refer here to Cole and the two security guards)
Like I said though, better than I thought it would be. And I agree with Calleja, we'll see where it goes after Zach Braff leaves and this show needs to find someone else to keep it afloat.