On the downside, Nick, you'd probably have to sometimes read big profile new comics, like events at least, to draw more viewers. But you'd use that influx to talk about the stuff you care about in other videos.
I will say that as someone who likes listening/watching people talk comics while I play Hearthstone, I value knowledge over flashiness. I also know that's in small commodity on YouTube and people seek out more content than is available, especially getting away from the kind of Youtuber who thinks Ms. Marvel is terrorist propaganda.
In a nutshell, though success might lean towards sometimes doing videos on things you've been avoiding, you'd certainly be a force of good in that field, even if your early videos are just you talking to the camera ... which also what the big shot comic Youtubes do anyway
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