BANG- this ones a great crowd pleaser. It's best played with 4 or more but the goal is simple. Kill someone. Well technically WHO you kill depends on what Role you draw. There is the Sheriff who needs to kill the Outlaws and the Renegade, the Deputy who needs to keep the Sheriff alive, the Outlaws who need to kill the Sheriff, and the Renegade who needs to be the last man standing. The game is played only using a deck of cards that consist of Bang cards (shoot), missed cards, items, and events. Oh, and when the game begins you only know who the Sheriff is. You have to kill another player for them to reveal their role. Usually this means that the outlaws will be gunning for the Sheriff, and the Deputy and the Renegade will be gunning for the Outlaws (the renegade MUST kill the Sheriff last or the Outlaws win even if they are dead), and the Sheriff is trying to figure out who his Deputy is while he takes the majority of the fire and defends himself.
Each player also randomly draws a character that comes with a special power. One allows you to draw a card whenever you are hit, one that allows you to heal if you discard cards from your hand, etc.
Your placement at the table also limits your ability to shoot other players. Everyone starts with a weapon with a range of 1. A 1 allows you to attack the people on each side of you. But you'll need a 2 to hit the next person around the table, and so on. A lot of items can help you achieve this, but there are a lot of items that can increase your range away from people as well (such as the Mustang). Killing the person next to you also reduces the range on the next person in line by 1 (because he's no longer in the game).
And once you start to lose interest in the game you can get expansion packs that add additional cards, characters, and increases the max number of players from 7 to 8 (an extra Renegade is added to the game).
Games usually last about 20 min each, and there isn't a lot of setup/cleanup involved.