The ones I know of for sure:Are there any game/plot-related issues with taking as many Long Rests as you want? The first long rest I took was part of advancing the plot (Astarion et al.) but it's made me hesitate to take any long rests as a result. I almost avoid them as much as possible which makes the game a bit of a resource scarcity slog as a result.
In Act 1
If you rest too much the ritual in the Grove will finish and you will get locked out, unless you get Kahga to stop it or you finish the goblin fort.
Once you go to the Duegar fort, you need to save Nere without resting or he just dies.
Once you find out about the prisoners you have a few long rests, but if you take too many they will die