The latest out of MLB is the possibility of a three-division setup where everyone "stays in their division" for the entire year. This would mean 12 games against nine other teams - those currently in your division and those in the division of the other league, for a total of 108 games.
Just doing a little "prediction" thing based on runs scoring/allowed from last year and division records with interleague play , I came up with the following standings for each "division" (projected wins/108 games):
Central - MIN 65.5, CLE 62.7, STL 61.8, CHC 58.0, MIL 56.9, CIN 50.2, CHW 47.7, PIT 45.2, KCR 43.4, DET 30.9
East - NYY 70.6, WSN 64.6, ATL 64.0, TBR 63.9, NYM 59.8, BOS 54.6, PHI 52.7, TOR 43.7, MIA 38.4, BAL 36.6
West - HOU 74.1, LAD 70.8, OAK 63.7, ARI 58.7, SFG 51.0, TEX 48.5, LAA 47.4, SDP 46.7, COL 45.8, SEA 42.9