I haven't read the paper from the study but this guy's lab uses baculovirus as a vector for intranasal protection in mice. I'm going to laugh when malaria, going through its life cycles, infects these mosquitoes making them carriers of both the parasite and the vector, and essentially gets 'injected' at the same time as the baculovirus vector. Normally the parasite induces apoptotic deletion of vaccine-specific memory B cells, long-lived plasma cells, and CD4+ T cells, resulting in failure of the naturally boosting antibody response to malaria parasites during infection. So now you get carriers that also harbor this recombinant malaria protein which is supposed to circumvent that bypass of immunological memory, but can't due to the the malaria fuckers getting to work before it has a chance to be effective.
