Very few, if any issues for me. But there is one.
I have an NTFS-formatted external drive. I hooked it up when I had the public RC installed, then I replaced that with a newer RC build, then the RTM build that some dude from Levovo leaked just after the OEMs got their copies. (key, anyone? Please? Pretty please?)
The ownership of the folders on that external drive got borked, since after a reinstall, the unique identifier for the previous "owner" was gone. any file manipulation required admin approval, and trying to move or delete files while in apps like ACDSee got "access denied".
By going in and making myself the owner of the folders once again instead of some weird string of letters and numbers ID'ing the previous me from the last install, I'm able to move files and folders at will again.
The only problem is getting rid of that "other" me from the last install. I keep getting errors because I'm never in what Win7 considers the final "parent" folder from which permissions were inherited down the line.