Dear [insert your name here]:
Thank you for the interest you've shown in considering a Nemesis position with First Lady Puffinstuff.
Your qualifications have been reviewed by members of our management team. While your background is an interesting one, we have received a number of applications from people whose qualifications more closely match the needs of our First Lady.
We would like to thank you once again for your interest in First Lady Puffinstuff, and wish you continued success in the pursuit of your arch enemy objectives.
Very truly yours,
FLP
P.S. Dear nemesis, you know who you are, this doesn't apply to you.