During football season you field a team based on your roster filling in the different positions on the team. In the House of Pain this is 1 QB, 1 RB, 1 WR 2 WR/RB, 1 TE, 1 Kicker, and a Defense. The rest of your roster is benched for that week. As the actual games played out you'll be rewarded points based on the stats of your starters. Come Tuesday morning if you have more points than your opponent for the week you pick up the win.
Honestly there's not much work involved, and it really helps make games you wouldn't normally care about more interesting.